YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
金属キレートによるOxalacetic Acidの脱炭酸反応(第3報)金属-ペプチド系について
山根 靖弘山次 信幸小柏 正宮崎 元一
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1977 年 97 巻 1 号 p. 76-81

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Effect of the metal-peptide systems on decarboxylation of oxa1acetic acid was examined, using copper(II), manganese(II), and nickel(II) as metals, and as peptide ligands, glycyl-glycine glycyl-alanine, glycyl-leucine, glycyl-threonine, glycyl-tyrosine, alanyl-glycine, leucyl-glycine, alanyl-alanine, histidyl-histidine, glycyl-glycyl-glycine, and glycyl-g1ycyl-g1ycy1-glycine. Among the metal-dipeptide systems, the fastest decarboxylation was observed when copper or manganese to His-His ratio was 1 : 1. None of the nickel-dipeptide systems decarboxylated oxalacetic acid faster than nickel(II) ion did. Decarboxylation studies were carried out at the rate of metal to ligand of 1 : 1, using copper(II), nickel(II), and manganese(II) as metals, and amino acid, di-, tri-, and tetra-peptide as ligands. The reaction rate for copper ligand decreased in the order of Gly>Gly-Gly>Gly-Gly-Gly=Gly-Gly-Gly-Gly for nickel-ligand in the order of Gly>Gly-Gly=Gly-Gly-Gly=Gly-Gly-Gly-Gly, and for manganese-ligand, in the order of Gly<Gly-Gly<Gly-Gly-Gly=Gly-Gly-Gly-Gly.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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