ヘッドスペースガスのガスクロマトグラフィーによる薬剤中のエタノールの簡易定量法(第2報)チンキ剤以外の液剤

抄録

A simple quantitative determination of ethanol in 14 samples of liquid drugs, excluding tinctures, was attempted by head-space gas chromatography. The apparatus used was chiefly a gas chromatograph equipped with a hydrogen flame ionization detector. Column packings were 5% PEG 20 M/Chamelite or 5% Reoplex 400/Chromosorb. Gas chromatograms derived from untreated liquid drugs did not present any peak which disturbed the calculation of ethanol content. When propanol was used as an internal standard, ethanol content calculated by the head-space technique resembled the values determined by the conventional three methods of JP 9, alcohol-meter, and dichromate oxidation in the case of higher concentration of ethanol. However, ethanol content resembles the values determined by the method of dichromate oxidation in the case of samples with concentrations lower than about 10% (v/v). Therefore, the head-space technique, as well as the method of dichromate oxidation, is applicable to the simple quantitative determination of lower concentration of ethanol.