YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
プリン誘導体によるフラビン類の光分解抑制およびそのケイ光消光との対応
岡野 定輔田中 照夫奈良 武志
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1977 年 97 巻 11 号 p. 1257-1260

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Studies were made on the effect of purine nucleosides and nucleotides on the photodecomposition of riboflavine, riboflavine 5'-phosphate, and flavine-adenine dinucleotide, and also on the intermolecular interaction between flavines and purine derivatives. The photodecomposition of flavines was found to be inhibited by purine derivatives, and the inhibitory effect was compared in terms of apparent first-order rate constant (K) of photodecomposition of flavines. The intermolecular interaction was studied from the point of fluorescence quenching of flavines by purine derivatives, and the quenching effect was compared in terms of association constant (KA) of the flavine-purine complexes. Irrespective of the kind of flavines involved, values of K and KA were in parallel, with decreasing order of guanosine, adenine, adenosine, 5'-guanylic acid, 5'-adenylic acid, adenosine triphosphate, inosine, and inosinic acid.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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