1977 年 97 巻 3 号 p. 289-294
Some pharmacological actions related to analgesic and anti-inflammatory activities of 5-aminomethylsalicylic acid (AMS) were investigated. (1) Analgesic activity of AMS (100-200 mg/kg, s.c.) was about twice as potent as that of salicylamide (200 mg/kg, s.c.) and the effect persisted for about 150 min. (2) AMS (100 mg/kg, s.c.) inhibited carrageenin-induced paw edema by approximately 36% and the activity was the same as that of sodium salicylate (100 mg/kg, s.c.). (3) AMS (200 mg/kg, s.c.) increased the excretion of uric acid and the activity was slightly more potent than phenylbutazone (30 mg/kg, p.o.). (4) AMS (10-5 M) inhibited the serum plasmin activity. (5) AMS (200 mg/kg, s.c.) slightly enhanced the increased vascular permeability induced by histamine. (6) AMS did not affect the effluent volume of the perfused ear vessel in the rabbit. (7) AMS (100-200 mg/kg, s.c.) slightly increased the blood sugar level in the rabbit.