Isopropamide Iodideのラット胃腸管吸収におよぼすトリクロロ酢酸の併用効果

抄録

Pharmacological response and diameter of a pupil in the rat were examined after oral administration of isopropamide iodide when given in combination with 50-fold molar excess of trichloroacetate in solution and compared with those after single administration of isopropamide iodide. However, the increased pharmacological activity, as reported by Irwin and others in 1969 using male albino mice, was not observed and the decrease in the response was seen in the presence of trichloroacetate. This fact could better be related to the inhibition behavior in stomach emptying of trichloroacetate through the direct effect on the stomach wall. Absorption study using the rat small intestine in situ and in vivo indicated that trichloroacetate (50-fold molar excess) enhanced the absorption rate of isopropamide iodide but unfortunately the above result could not explain the pharmacological response in this study. A great care should be taken for explanation and presumption of pharmacological response by applying the data of in situ and in vivo studies using a part of the animal body.