YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ヘテロ環化合物の研究(第29報)2-[α-(N-Substituted carbamoyl)-β-(5-nitro-2-furyl)vinyl]furan誘導体, および2-[α-(N'-Substituted ureido)-β-(5-nitro-2-furyl)vinyl]furan誘導体の合成
吉名 重多賀田中 昭臼井 敏直
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1977 年 97 巻 9 号 p. 1007-1012

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Eighteen kinds of 2-[α-(N-substituted carbamoyl)-β-(5-nitro-2-furyl) vinyl] furans were prepared. 2-[α-Isocyanato-β-(5-nitro-2-furyl) vinyl] furan, 2-[α-amino-β-(5-nitro-2-furyl) vinyl] furan, and 2-[β-(5-nitro-2-furyl) ethynyl] furan were obtained by the thermolysis of 2-[α-azidocarbonyl-β-(5-nitro-2-furyl) vinyl] furan. Fourteen kinds of 2-[α-(N'-substituted ureido)-β-(5-nitro-2-furyl) vinyl] furans were also prepared. 2-[α-(N-Methylcarbamoyl)-β-(5-nitro-2-furyl) vinyl] furan and 2-[α-(N-ω-hydroxyethylcarbamoyl)-β-(5-nitro-2-furyl) vinyl] furan exhibited a prominent antibacterial activity in vitro against gram-positive and gram-negative bacteria.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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