1977 年 97 巻 9 号 p. 1022-1033
Eighty-four compounds (mainly N-heteroaromatic compounds) were synthesized and their antitumor activity was examined. Four quinoline derivatives were found to have some antitumor effect on the solid type of Ehrlich carcinoma. These compounds were, 3-hydroxy-6-quinolinecarbonitrile (sample No. 7-III), 6-bromoquinaldic acid 1-oxide (No. 7-VIII), 8-(hydroxyimino)-5, 6, 7, 8-tetrahydroquinoline (No. 7-XIX) and 4-(hydroxyimino)-1, 2, 3, 4-tetrahydroacridine (No. 7-XX). No other derivatives were found effective.