YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ヘテロ環化合物の研究(第33報)Furo[3,2-c]pyrazole誘導体の合成 その1Furo[3,2-c]pyrazole類の合成化学的研究
吉名 重多賀田中 昭郭 盛助
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1977 年 97 巻 9 号 p. 955-961

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Reaction of 5-substituted 2-furyl phenyl ketones and phenylhydrazine afforded the corresponding phenylhydrazones (A). Majority of these hydrazones were separated into E-form and Z-form compounds, and their steric configuration was determined from their nuclear magnetic resonance spectra. Treatment of these hydrazones with lead tetraacetate and cyclization with boron trifluoride etherate afforded furo [3, 2-c] pyrazoles when the furan ring possessed a methyl, hydrogen, or a bromine atom in 5-position, while indazoles were produced when the substituent (s) was methoxycarbonyl or nitro group.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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