YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
β-ラクタム系抗生物質の薬学的研究(第2報)D(-)-α-[Dioxo-1-piperazinecarboxamido]benzylpenicillin誘導体の合成ならびに構造-抗菌活性
才川 勇高野 俊太郎吉田 長作高島 億太桃井 海秀保田 隆加須屋 興子小松 美和子
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1977 年 97 巻 9 号 p. 980-986

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D (-)-α-(4-Substituted 2, 3-dioxo-1-piperazinecarboxamido) benzylpenicillin (I), D (-)-α-(4-substituted 2, 5-dioxo-1-piperazinecarboxamido) benzylpenicillin (II) and D (-)-α-(4-substituted 3, 5-dioxo-1-piperazinecarboxamido) benzylpenicillin (III) were prepared. These compounds showed in vitro antibacterial activity against S. aureus, E. coli, P. aeruginosa, P. vulgaris, K. pneumoniae, and S. marcescens, the activity being in the order of I>II, III. These compounds were found to have a stronger antibacterial activity against gram-negative bacilli than aminobenzylpenicillin or carbenicillin.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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