1977 年 97 巻 9 号 p. 995-1001
Degradation pattern of 6-[D (-)-α-(4-ethyl-2, 3-dioxo-1-piperazinecarboxamido) phenylacetamido] penicillanic acid (T-1220) in aqueous solution was investigated. In acidic solution, T-1220B and T-1220D were found, while T-1220A, T-1220B, and T-1220C were identified in alkaline solution. Stability of T-1220 in aqueous solution and body fluid was measured by means of High Pressure Liquid Chromatography. T-1220 was more stable at neutral pH of 5.0-6.0, slightly unstable at acidic pH of 4.0, and markedly unstable at alkaline pH of 9.0. Stability of T-1220 in various body fluids seemed to depend on pH, and its degradation pattern was similar to that in aqueous solution.