ピリダジノン誘導体の研究(第9報)2,4,5-トリ置換-3(2H)-ピリダジノン類の合成と止血作用

抄録

In order to examine hemostatic activity, 5-alkoxy-4-hydroxy-2-methyl-3 (2H)-pyridazinones (V, VIa-d) and 4-substituted 2-methyl- or 2-phenyl-5-methylsulfonyl-3 (2H)-pyridazinones (XIa-f) were prepared. Among the compounds prepared, sodium 5-ethoxy-2-methyl-3-oxo-4-pyridazinolate (V), 4-hydroxy-2-methyl-5-methylsulfonyl-3 (2H)-pyridazinone (XIa), 4-(3-dimethylaminopropylamino)-2-methyl-5-methylsulfonyl-3 (2H)-pyridazinone (XIh), and 4-hydrazino-2-methyl-5-methylsulfonyl-3 (2H)-pyridazinone (XIj) showed activity for shortening the bleeding time comparable to carbazochrom sodium sulfonate (I).