ラット血清成分に及ぼす漢方方剤の影響(第1報)
1978 年 98 巻 12 号 p. 1642-1650
詳細
1978 年 98 巻 12 号 p. 1642-1650
The effect of extracts from 6 varieties of Kanpo-prescriptions (Saiko-Keishi-Kankyo-Toh, Shakuyaku-Kanzoh-Toh, Shoseiryu-Toh, Sho-Saiko-Toh, and Otsuji-Toh) on rat serum constituents at 6 hr after intraperitoneal administration was examined. Estimation of serum constituent concentrations were carried out with an automatic method. Administration of the extracts resulted in decrease of blood urea nitrogen (BUN) and increase of total cholesterol (T. Chol.) concentration in rat serum. In rats treated with Saiko-Keishi-Kankyo-Toh, BUN was maximally decreased at 6-8 hr (30%) and T. Chol. was maximally increased at 8-12 hr (21%). In Shakuyaku-Kanzoh-Toh administration, BUN was maximally decreased at 4-8 hr (46%) and T. Chol. was maximally increased at 6-12 hr (33%). In Sanoh-Shashin-Toh administration, BUN was maximally decreased at 6-8 hr (45%) and T. Chol. was maximally increased at 8-12 hr (39%). Concentrations of glucose, tri-glyceride and uric acid were not different from the control values. Furthermore, the most effective dose for each crude extract from 3 varieties of Kanpo-prescriptions was 10-20 mg/rat.
