YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ヌクレオシド類と塩化水銀および塩化カドミウムの錯形成能について
権田 金治古賀 正三坂口 正一宮田 義久小倉 治夫岡本 敏彦
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1978 年 98 巻 6 号 p. 708-714

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Through the observation of chemical shifts in nuclear magnetic resonance spectra, formation constants of 1 : 1 metal complexes with nucleosides were found in dimethyl sulfoxide at room temperature. The complex formation constants of CdCl2-adenine and CdCl2-benzyladenine are 1.6-1.7 times larger than the values for the HgCl2 complexes of adenine and benzyladenine. On the other hand, the formation constant of HgCl2-6-mercaptopurine is larger than the value of CdCl2-6-mercaptopurine. 6-Methylmercaptopurine did not complex with HgCl2 or CdCl2. In nucleosides, the complex formation constant with HgCl2 is in the order of 4-thiouridine, cyclocytidine, and cytidine. The complex formation with HgCl2 or CdCl2 was not observed with nucleoside analogs prepared from 5, 6-diamino-1, 3-dimethyluracil with D-glucose or D-galactose.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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