1978 年 98 巻 6 号 p. 708-714
Through the observation of chemical shifts in nuclear magnetic resonance spectra, formation constants of 1 : 1 metal complexes with nucleosides were found in dimethyl sulfoxide at room temperature. The complex formation constants of CdCl2-adenine and CdCl2-benzyladenine are 1.6-1.7 times larger than the values for the HgCl2 complexes of adenine and benzyladenine. On the other hand, the formation constant of HgCl2-6-mercaptopurine is larger than the value of CdCl2-6-mercaptopurine. 6-Methylmercaptopurine did not complex with HgCl2 or CdCl2. In nucleosides, the complex formation constant with HgCl2 is in the order of 4-thiouridine, cyclocytidine, and cytidine. The complex formation with HgCl2 or CdCl2 was not observed with nucleoside analogs prepared from 5, 6-diamino-1, 3-dimethyluracil with D-glucose or D-galactose.