Intravenous injection of parotin to rabbits results in leukocytopenia from 5 min after the injection, and a biphasic change of decrease to 10 min and increase after 20 min of injection was observed. This leukocytosis-promoting activity of parotin was also observed in splenectomized, adrenalectomized, or nephrectomized rabbits. This leukocytosis-promoting activity of parotin was found to appear even in rabbits with liver damage due to carbon tetrachloride.
