o-Chloro-α-(tert-butylaminomethyl)benzylalcohol Hydrochloride(C-78)および関連化合物の合成と気管支拡張作用

抄録

For the development of a new bronchodilator, chloro-substituted α-(tert-butylamino-methyl) benzyl alcohols (VIIa-c) were synthesized via glyoxal derivatives. Further, hydroxy-substituted derivatives (VIII, IXa-e) of VIIa were synthesized by several methods. Among these compounds, o-chlorobenzyl alcohol hydrochloride (C-78) had a strong effect, and its 4-hydroxy derivative showed a strong effect, comparable to Salbutamol.