YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Studies on the Synthesis of Chemotherapeutics. VI. Synthesis of 6- and 7- Carbamoyl-1, 4-dihydro-4-oxoquinoline-3-carboxylic Acid Derivatives : Studies on the Syntheses of Heterocyclic Compounds. DCCLXI
TETSUJI KAMETANIKAZUO KIGASAWAMINEHARU HIIRAGIKIKUO WAKISAKASEIJI HAGAOSAMU KUSAMAHIDEO SUGIKUMEO KAWASAKIKEIZO TANIGAWA
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1978 Volume 98 Issue 9 Pages 1291-1296

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Abstract

In order to evaluate their antimicrobial activity, 6- and 7-carbamoyl-1-ethyl-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid derivatives (2) were prepared. Thermal cyclization of diethyl N-(4- and 3-carbamoylphenyl) aminomethylenemalonates gave 6- and 7-carbamoylquinolines, which, on alkylation followed by hydrolysis, afforded 2.

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