YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Butyrophenone系薬物に関する生物薬剤学的研究(第2報)ラット赤血球膜安定化作用
相本 太刀夫増成 敏江村田 敏郎
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ジャーナル フリー

1979 年 99 巻 1 号 p. 106-108

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Stabilization of the rat erythrocyte membrane by neuroleptic butyrophenones such as moperone, haloperidol, trifluperidol, clofluperol, floropipamide, and lenperone was examined. In low concentrations, all drugs used stabilized rat erythrocytes against hypotonic hemolysis, while at higher drug concentrations, the antihemolytic activities decreased along with increasing drug concentration. Clofluperol, the most potent neuroleptic of the drugs used, showed the highest antihemolytic activity and floropipamide, the least potent neuroleptic, showed the lowest. A good correlation was obtained between the partition coefficient (n-octanol/0.15 M phosphate buffer, pH 7.4) and antihemolytic activity of the drugs.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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