1979 年 99 巻 1 号 p. 45-50
The effects of hog pancreatic kininogenase (Hog Panc. K.) on blood pressure and plasma kininogen level in normal and renal hypertensive rabbits were studied. Intramuscular injection of Hog Panc. K. resulted in a dose-dependent vasodepressor action in normal rabbits, and this action was more pronounced in renal hypertensive rabbits. Intravenous, intramuscular and intraduodenal administration of Hog Panc. K. led to the consumption of plasma kininogen in normal rabbits, however, their total plasma protein levels did not change. Both the vasodepressor response and the consumption of plasma kininogen by Hog. Panc. K. seemed to be dose-dependent in renal hypertensive rabbits. In renal hypertensive rabbits the level of plasma kininogen was 1.7 times higher than in normal rabbits, while the vasodepressor effect of Hog Panc. K. did not appear in spontaneously hypertensive rats. Kinin formation by various kininogenases from plasma kininogen obtained from various animals was also examined. Hog Panc. K. caused a kinin-liberation from the crude kininogen preparations obtained from human, bovine, hog, dog and rabbit plasma, but not from that of guinea pig and rat.