YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
アロキサン糖尿ウサギの血小板粘着能および凝集能に対するGliclazideの抑制効果
桑島 淳二坪井 俊紀小宮 雅信藤谷 武一中村 恵二前田 淳子金子 博美吉田 耕一清水 当尚
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1979 年 99 巻 1 号 p. 59-64

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The inhibitory effect of gliclazide, a new sulfonylurea, on platelet function was examined in alloxan diabetic rabbits. The blood glucose level in diabetic rabbits was about 3 times higher than in normal rabbits, and the plasma insulin level was below 50% of that of normal rabbits. Platelet adhesiveness to glass beads and platelet aggregation by collagen were markedly enhanced in the diabetic rabbits. 2-4 week daily administration of gliclazide (100 mg/kg, p.o.) to diabetic rabbits effected the reduction of enhanced platelet adhesiveness, and platelet aggregation was also lowered to that of normal rabbits after 4 weeks. Blood glucose and plasma insulin levels, however, were not changed by the treatment. These results suggest that gliclazide exerts an inhibitory action on platelet function via mechanism (s) other than insulin secretion and glucose metabolism.

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