YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ラット血清成分に及ぼす和漢薬の影響(第2報)
長澤 哲郎渋谷 眞也大浦 彦吉
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1979 年 99 巻 1 号 p. 71-77

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We investigated the effects of crude extracts from 15 varieties of crude drugs on blood urea nitrogen (BUN) and total cholesterol (T. Chol.) concentrations in rat serum at 8 hr after intraperitoneal administration. Concentrations were estimated by an automatic method. We found that the administration of rhei rhizoma, coptidis rhizoma, ephedrae herba, paeoniae radix, and bupleuri radix, resulted in a decrease of BUN and an increase of T. Chol. while administration of asiasari radix and cinnamomi ramulus, resulted in an increase of T. Chol. only. In addition, we found that the most effective doses of rhei rhizoma, coptidis rhizoma, ephedrae herba, and paeoniae radix were 5, 5, 5 and 25 mg/rat on BUN and 5, 5, 2.5 and 25 mg/rat on T. Chol., respectively. In rats treated with 5 mg rhei rhizoma, 5 mg coptidis rhizoma or 25 mg paeoniae radix, BUN was maximally decreased at 6 hr and T. Chol. was maximally increased at 8 hr. In rats administered 5 mg scutellariae radix or 25 mg glycyrrhizae radix BUN was maximally decreased at 4 hr and T. Chol. was maximally increased at 6 hr, although BUN and T. Chol concentrations were not affected at 8 hr after the 5 mg scutellariae radix or 5 mg glycyrrhizae radix.

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