YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
オキサゾールカルボン酸誘導体の合成(第16報)アミノオキサゾール類の還元的開裂について その9 2-Aminoxazole類の還元的開裂における触媒量の影響
田中 千秋栗山 しのぶ
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1979 年 99 巻 1 号 p. 78-82

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Various 2-aminoxazoles (I) and 2-acetamidoxazoles (IV) were submitted to catalytic reduction using varying amounts of palladium-carbon or platinum oxide catalyst. In all cases, in which a large amount of catalyst was used, the ring fission occurred preferentially and I was mainly converted to alkylureas (V) via (E)-alkenylureas (II). As the amount of catalyst decreased, the rate of cis-2-amino-2-oxazolines (III) increased, suggesting that the hydrogenolysis reaction pathway of I was determined by the step of the conversion of the half-hydrogenated species to the intermediates (II, III) in terms of the Horiuti-Polanyi mechanism.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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