1979 年 99 巻 2 号 p. 114-119
Reactivity of the purine ring to Grignard reagents was examined with 9-phenyl-9H-purine (I) and 7-phenyl-7H-purine (II). Hydrolysis of the additive (s) formed by the reaction of I and the Grignard agent afforded 6-substituted 1, 6-dihydro-9-phenyl-9H-purine (I'). In the case of II, the phenyl group in 7-position produced steric hindrance in this reaction and the alkyl or phenyl group was not introduced into the 6-position, and 8-substituted 8, 9-dihydro-7-phenyl-7H-purine (II') was formed. Oxidation of I'and II'with alkaline ferricyanide respectively afforded 6-substituted 9-phenyl-9H-purine (I") and 8-substituted 7-phenyl-7H-purine (II").