Studies on the Syntheses of Heterocyclic Compounds. DCCLXXVI. Cyclisation Reaction of N-Substituted Mandelohydrazide with Formaldehyde

Abstract

Acid-catalysed cyclisation of N-substituted mandelohydrazides (II) and X with paraformaldehyde gave hexahydro-1, 2, 4, 5-tetrazine derivatives. Furthermore, the acetyl group on the nitrogen rearranged to alcoholic oxygen during the cyclisation of X so as to give VI.