1979 年 99 巻 2 号 p. 180-186
The theories of drug release from the pinhole of sphere (System-1) and drug release from the slot of sectoral wedge (System-2) are presented and drug release from System-1 was measured, using a sulfamethxazol (SMX) sphere coated with beeswax. The simulation technique for System-1, using a digital computer can be applied to the dissolution of SMX, the amount of SMX dissolved was calculated step by step on the basis of the Nernst-Brunner's dissolution model, and a good agreement was found between the calculated and measured amount of SMX. The simulation technique for System-2 can be applied to Brooke-Washkuhn experiments and a good agreement was found between the calculated and measured amount of stearic acid from System-2. The proposed theories and simulation techniques are applicable to various drug delivery systems with various geometry and are useful for the selection of the ideal form.