YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
制癌薬に関する薬物相互作用(第2報)免疫賦活薬投与マウスにおけるシクロホスファミドの抗腫瘍作用
佐々木 健一斎藤 正明高柳 義一
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1979 年 99 巻 2 号 p. 187-191

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The antitumor activities of cyclophosphamide (CPA) on Ehrlich solid tumor in mice were examined alone and in combination with immunopotentiators. Killed Mycobacterium butyricum (MB), OK-432 (Picibanil) and lipopolysaccharide (E. coli, LPS) prolonged the pentobarbital-induced sleeping time of mice with dose-dependence. MB and LPS markedly inhibited the antitumor activity of CPA. In MB-or LPS-treated mice, the analgesic action of aminopyrine was increased and the action of codeine phosphate was decreased. These immunopotentiators may change the activity of combined drugs by inhibition of the hepatic microsomal drug-metabolizing system.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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