Purines. IV. Condensation of 8-Methyl-9-phenyl-9H-purine or 8-Methyl-7-phenyl-7H-purine with Aldehyde

Abstract

The methyl group in 8-methyl-9-phenyl-9H-purine (I) and 8-methyl-7-phenyl-7H-purine (II) undergoes condensation with aromatic aldehydes (III) to give 8-(2-arylethenyl)-9-phenyl-9H-purine (IV) and 8-(2-arylethylenyl)-7-phenyl-7H-purine (V). In general, better result was obtained by refluxing in methanol, in the presence of sodium methoxide (B method), than by heating in the presence of acetic anhydride at 190-200°(A method).