YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ヨウ素法によるコール酸ナトリウムのミセル形成臨界濃度の測定
大塚 昭信米澤 頼信渡辺 淳子
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ジャーナル フリー

1979 年 99 巻 2 号 p. 217-219

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The critical micelle concentration (cmc) of sodium cholate in aqueous solution was determined by the iodine method. The apparent value of cmc was affected by the concentration of iodine added. In order to determine the corrected value of cmc, it is therefore necessary to extrapolate of the iodine concent ration to zero. The corrected cmc value by this method was in good agreement with the cmc values in the literature determined by various other methods. Since the physiological activities of bile salts were considered to be greatly influenced by the environment of the gastrointestinal tract, the effect of pH and ionic strength on the cmc value of sodium cholate was examined. The value of cmc decreased with lowering pH and with increasing ionic strength.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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