Yonago Acta Medica
Online ISSN : 1346-8049
ISSN-L : 0513-5710
Original Article
Decreased Wave V Amplitude in Auditory Brainstem Responses of Children with Cerebellar Lesions
Yuka MatsuuraMasayoshi OguriYoshiaki SaitoYasutaka AoeAyame OgawaShota AkiyamaNanako YasudaKengo SatoYoshihiro MaegakiYasuaki Hirooka
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2018 Volume 61 Issue 4 Pages 220-227


Background This study aims to elucidate the effect of isolated cerebellar lesions sparing the brainstem on the auditory brainstem responses in children.

Methods We enrolled 10 children (aged 1–16 years) with cerebellar lesions on neuroimaging but lacking clinical brainstem involvement signs and with normal brainstem volumes on magnetic resonance imaging.

Results The interpeak latency of waves I and V was normal in 9 patients and was marginally prolonged in 1 patient. While amplitudes of waves I and III were normal, we noted a decreased amplitude of wave V and/or an increased I/V amplitude ratio in 6 patients; these included 5 of 8 patients with cerebellar hypoplasia/atrophy and 1 patient with acute cerebellar ataxia.

Conclusion Our results support the hypothesis of an inhibitory input from the cerebellar fastigial nucleus on the inferior colliculus, which might be disinhibited because of Purkinje cells dysfunction due to cerebellar cortex lesions, especially within the cerebellar vermis.

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© 2018 Tottori University Faculty of Medicine
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