Yamaguchi Medical Journal
Online ISSN : 1880-4462
Print ISSN : 0513-1731
ISSN-L : 0513-1731
Case Report
A Case of Local Advanced Colorectal Cancer, for Which Radical Surgery is Difficult, Responding Well to Neoadjuvant Chemotherapy(SOX+Bevacizumab)and Subsequently Resected Surgically.
Hidefumi KUBOYuta KIMURAToru KAWAOKAMakoto MIYAHARARyouichi SHIMIZUYoshimi YAMASHITA
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2017 Volume 66 Issue 2 Pages 139-144

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Abstract

We present a surgical case of locally advanced colorectal cancer after neoadjuvant chemotherapy. The case was a man in him 60s, he had sigmoid colon cancer. The tumor was large mass and spread from the urinary bladder to abdominal wall. He had few symptom of ileus, so we performd neoadjuvant chemotherapy with S-1 and oxaliplatin(SOX)plus Bevacizumab for four cycles to him.

After neoadjuvant chemotherapy, objective tumor shrinkage was observed with this case, and treatment resulted in a partial response by Response Evaluation Criteria in Solid Tumors(RECIST).

The case was underwent safety surgery with no residual margin.

In conclusion, neoadjuvant chemotherapy with SOX or mFOLFOX6+ B-mab may safe and improve surgical rate with no residual margin. Further studies on neoadjuvant chemotherapy for locally advanced colorectal cancer will be need about survival data such as PFS and OS.

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© 2017 by Yamaguchi University Medical Association
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