2017 Volume 66 Issue 2 Pages 89-96
The lipid-lowering therapy by statins may stabilize and reduce coronary plaques. We compare the effect of strong or moderate statins on the coronary plaque characteristics by using 64-slice multidetector computed tomography （MDCT）．
Methods and Results
We analyzed 13 subjects with non-calcified coronary plaques（NCP）as determined by MDCT. Pitavastatin（PTV：2mg/day）or pravastatin（PRA：10mg/day）were randomly administered. MDCT were performed at 0, 6 and 12 months after lipid-lowering therapy. In PTV group（n=6），CT density of NCP increased by 35.6 ± 28.8 HU after 6 months（p=0.037）and by 30.6 ± 29.8 HU after 12 months（NS）．NCP area was decreased by 35.9 ± 15.2 % after 6 months and by 41.0 ± 16.5 % after 12 months（both P=0.001）．In PRA group（n=7），CT density of NCP did not significantly increased after 6 months（NS）and after 12 months（NS）．NCP area was not significantly decreased at 6 months（NS），but decreased by 23.1 ± 16.7 % at 12 months（P=0.001）．
Serial CT angiography revealed that the regression of NCP occurs rapidly by strong lipid lowering therapy compared to the moderate statin therapy.