Japanese Journal of Infectious Diseases
Online ISSN : 1884-2836
Print ISSN : 1344-6304
ISSN-L : 1344-6304
Original Article
The Antibacterial Effects of Antimicrobial Peptides OP-145 against Clinically Isolated Multi-Resistant Strains
Liu MingJian-An Huang
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2017 Volume 70 Issue 6 Pages 601-603


OP-145 is a synthetic antimicrobial peptide developed from the human cathelicidin LL-37. The purpose of this investigation was to evaluate the effect of the antimicrobial peptide OP-145 against clinically isolated drug-resistant strains. Ten methicillin-resistant Staphylococcus aureus (MRSA) strains were obtained from our hospital's clinical inspection center, and the activity of OP-145 on growth and biofilm formation of these strains was evaluated by colony counts and scanning electron microscopy. The antimicrobial peptide OP-145 showed significant antibacterial activity against 9 MRSA strains. For the biofilm experiments, MRSA counts in the biofilms decreased significantly after 24 h (P < 0.05). OP-145 strongly reduced growth and biofilm formation of clinically isolated drug-resistant strains in vitro, and the use of this class of antimicrobial agents may be an important new approach in controlling bacterial infections.

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