Article ID: JJID.2016.047
This study was conducted to study the epidemiology and clinical manifestations of human metapneumovirus (hMPV) infection in children in the Suzhou area, China, and to investigate the effect of thymic stromal lymphopoietin (TSLP) on wheezing in hMPV-infected children. The study comprised 13 533 children with respiratory tract infection admitted to Children's Hospital of Soochow University between January 2009 and December 2014. Clinical data was recorded. The plasma levels of TSLP, IL4, and IL2 in 35 wheezing children with single hMPV infection and 15 non-wheezy children with hMPV infection and 35 wheezing children with other viral infections were compared. The annual rates of hMPV infection from 2009 to 2014 were 2.33%, 6.41%, 3.29%, 3.52%, 0.23%, and 0.64%, respectively, peaking in 2010. The average percentage of CD3-/CD16+/CD56+ in inpatients with hMPV infection only was significantly lower than that of other viral infections. The serum levels of TSLP and IL4 in wheezing children with hMPV infection was significantly higher than in other two groups. hMPV is a common viral pathogen causing respiratory infection in children in Suzhou, but annual rates have declined since 2010. The infection with hMPV may upset cell immunity. Serum TSLP levels were elevated after hMPV infection.