Article ID: JJID.2020.058
Seven species (A–G) of human mastadenovirus (HAdV) are known, and more than 100 types have been reported. HAdV is highly resistant to common hand sanitizers. Epidemic keratoconjunctivitis and pharyngoconjunctival fever caused by HAdV can be explosively transmitted in a confined space, resulting in outbreaks such as nosocomial infections. Given the absence of an antiviral agent for HAdV infection, it is important to prevent the spread of infection using disinfectants. The bactericidal and virucidal activities of ozone have already been known widely. ALTANT is an ozonated alcohol preparation developed by E-TECH Co., Ltd. (Kobe, Hyogo, Japan).
In this study, ALTANT was mixed with different types of HAdV at a ratio of 9:1, and the viability of the HAdV was determined after instantaneous reactions for varying time periods (flash (< 3 seconds) to 5 minutes) using TCID50 assay. The assay results demonstrated that the viability of the HAdV decreased by 1/10 to 1/100 within 1 minute after the reaction, albeit slight differences in the reactivity observed among HAdV types. The viability of the HAdV decreased by a factor of >4log10, and the virus was completely killed in 3 minutes. This study demonstrated that ALTANT has a potent HAdV disinfection effect.
