論文ID: JJID.2020.811
Human Immunodeficiency Virus (HIV) infection in pregnancy may result in adverse obstetric outcomes such as still birth. The present study aimed at comparing Stillbirth Rate (SBR) for HIV-infected pregnancy with that in general population, observing year-wise trends of HIV exposed SBR and identifying possible associated exposures. A retrospective cohort study was conducted through analysis of secondary data from 314 Integrated Counselling and Testing Centres across the state of West Bengal, India from 2012 to 2020. 3478 HIV-infected pregnancies were followed up and year wise SBR was compared with that among all pregnancies of the state as per latest available Sample Registration System report in India. Year wise trend of SBR through linear regression was performed. t Test for two means and Relative Risk (RR with 95% Confidence interval) were measured to identify association between different exposures and stillbirth. SBR was significantly higher (26.7/1000) in HIV-infected pregnancies than in all pregnancies (5/1000) and it was reduced significantly following Anti Retroviral Treatment (ART) initiation (RR=0.09:0.05 -0.16). The spouse testing for HIV (surrogate marker for familial involvement) (RR =0.35:0.20- 0.61) and maternal literacy (RR =0.62:0.40 -0.97) were also found significantly protective for stillbirth.
