A Case Report of Bacterial Meningitis Caused by an Emerging Strain of Penicillin-Resistant Non-vaccine Serotype 10A

抄録

The pneumococcal conjugate vaccines successfully decreased the incidence of invasive pneumococcal diseases and pneumococcal antibiotic resistance. However, it has also led to serotype replacement. According to the report from the National Institute of Infectious Diseases (NIID) in 2017, 96% of pneumococcal isolates obtained from IPD children aged <5 years were non-PCV13-serotype. Here, we report a Japanese immunocompetent and vaccinated child who developed refractory meningitis caused by Streptococcus pneumoniae, nonvaccine serotype 10A. PCR revealed genotypic penicillin-resistant Streptococcus pneumoniae (gPRSP) with triple mutations (pbp1a + 2b + 2x). Multilocus sequence typing identified the strain as sequence type (ST) 11189. ST11189 strain has not been reported in Japan, but has recently been reported as a cause of invasive infections in Korea. The clinical course was complicated by development of brain and subdural abscesses that necessitated prolonged antibiotic treatment and multiple burr hole drainages. Unfortunately, neurological sequelae remained. Continued molecular surveillance is needed to monitor emerging virulent clinical strains.