Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
INDUCTION AND CHARACTERIZATION OF SPLENIC SUPPRESSOR CELLS DIRECTED TO NATURAL KILLER CELLS IN JAPANESE QUAILS
AKIO YAMADAMASANORI HAYAMI
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1981 Volume 34 Issue 2 Pages 95-102

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Abstract

Intravenous inoculation of chicken amniotic fluid (ChAmF) markedly reduced natural killer (NK) cell activity of spleen cells from Japanese quails. The reduction of NK activity was mediated by non-adherent thymus-dependent lymphoid cells which were resistant to treatment with anti-immunoglobulin serum and sensitive to treatment with anti-thymocyte serum in the presence of complement. The suppressing activity was selectively directed to NK cells, since Rous sarcoma virus-specific cytotoxicity or hemagglutinating antibody production against sheep erythrocytes was not suppressed in ChAmF-treated quails. Spleen cells from normal 1-week-old quails had similar characteristics to those from ChAmF-treated 4-week-old quails, lacking NK activity and exhibiting suppressive effect on NK activity, and were also shown to be thymus-dependent. Biological significance of the presence of NK cells and their suppressor cells is discussed in relation to embryonic development and tumor-surveillance mechanism.

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