Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISOLATION OF VIRUS CAUSING HEMORRHAGIC FEVER WITH RENAL SYNDROME (HFRS) THROUGH A CELL CULTURE SYSTEM
TAKASHI KITAMURATOSHIHIKO KOMATSUKAZUYOSHI SUGIYAMACHIHARU MORITAKIYOSHI IMAIZUMISADASHI SHIGAYORIYUKI AKAOAKIRA OYAHISAO TAKEDAJIRO ARIKAWANOBUO HASHIMOTOSHOZO URASAWA
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1983 Volume 36 Issue 1 Pages 17-25

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Abstract

Twenty-three rat lung specimens collected in outbreaks of hemorrhagic fever with renal syndrome (HFRS) in three medical institutions were inoculated onto the VERO-E6 cell monolayers. After several blind passages, an agent growing serially in the cell cultures and reacting specifically with known HFRS-positive sera was isolated from two of these specimens. The two isolates were antigenically identical each other. The agent, named strain SR-11, was identified as the causative virus of HFRS by its antigenic identity with E6 cell-adapted HFRS virus, Hantaan 76-118 strain, and the specific reactions with sera from various HFRS cases.

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