Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
INFLUENCE OF IRON ON GROWTH AND EXTRACELLULAR PRODUCTS OF ACINETOBACTER BAUMANNII
Vikas Kumar GOELArti KAPILBimal DASD.N. RAO
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1998 Volume 51 Issue 1 Pages 25-33

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Abstract

Iron is an important nutrient required by bacteria for optimal growth. Acquisition of iron from the host where iron is restricted is an important mediator of bacterial pathogenesis. In iron deplete chemically defined medium (CDM-Fe) growth of Acinetobacter baumannii was restricted as compared to iron replete medium (CDM+Fe) . Bacteria developed four high molecular weight outer membrane proteins (OMPs) of 88, 84, 80 and 77 kDa in CDM-Fe medium which were absent in CDM+Fe medium, and are known iron regulated outer membrane proteins (IROMPs) . A. baumannii secreted siderophores extracellularly into the medium which act as iron chelators which had been demonstrated in the supernatants of CDM-Fe media. The siderophore was of catechol type. This shows that A. baumannii under iron restricted conditions express IROMPs along with production of catechol type siderophore in order to acquire iron from the external milieu.

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