有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
Review de Debut
ステロイド誘導体を活用する(+)-コルチスタチンAの全合成
庄司 宗生
著者情報
ジャーナル オープンアクセス

2009 年 67 巻 9 号 p. 949-950

詳細
抄録

Recent advances in synthetic studies on steroidal alkaloid, (+)-cortistatin A, are described. (+)-Cortistatin A shows a potent and selective anti-angiogenetic activity against human umbilical vein endothelial cells (HUVECs) at nM concentrations and expected as a novel anticancer drug candidate. (+)-Cortistatin A has attracted considerable attention of not only biologists but also synthetic chemists because of its unique highly functionalized abeo-9(10,19)-androstane structure and potent biological activity. Thus the total syntheses of (+)-cortistatin A have been reported by three groups and the synthetic studies are currently underway by several groups. This review focuses on synthetic approaches taking advantage of using steroidal derivatives through ring expansion reaction to construct the core structure of (+)-cortistatin A reported by Corey and Baran respectively.

著者関連情報
© 2009 社団法人 有機合成化学協会
前の記事 次の記事
feedback
Top