有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
総説および総合論文
創薬研究支援を指向した基板担持型パラジウムの開発
有澤 光弘星谷 尚亨周東 智
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ジャーナル 認証あり

2010 年 68 巻 9 号 p. 920-929

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In an effort to create reusable, Pd-leach-free catalysts, many heterogeneous catalysts have been developed with Pd immobilized on supports such as activated carbon, inorganic solids and polymers. Yet few of these immobilized Pd catalysts for C-C bond formations can claim both high recyclability (>10 times) and low Pd-leaching (<1 ppm).
We successfully developed a practical Pd material, SGPd (Sulfur-modified GaAs(001) supported Pd) and SAPd (Sulfur-modified Au supported Pd) whose Pd was immobilized on sulfur-modified GaAs(001) or Au, respectively. With the lowest Pd-releasing levels and high recyclability, this is one of the best Pd materials thus far developed. It became clear that actual active species is released Pd in the reaction mixture through detailed mechanistic experiments. Because it leaches extremely low levels of Pd into reaction mixtures, removal of the residual Pd is unnecessary especially using SAPd, even in syntheses involving pharmaceutical ingredients.

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