Carbon-Carbon Bond Formation by Way of Umpolung Strategy of Enamine Derivatives

Abstract

Umpolung chemistry has been the focus of research on organic synthesis due to its usefulness and unusual reactivity. Above all, umpolung of enamine property enables the formation of highly substituted carbon-carbon bonds and installation of aryl groups on sp³ carbon atoms, which are difficult to realize by normal enolate chemistry. This short review describes recent reports of the carbon-carbon bond formation by umpolung reactions of enamine derivatives.