海洋天然物アゲラスタチンAの合成

抄録

Pietra and co-workers reported isolation of (−)-agelastatins A and B from the deep water marine sponge Agelas dendromorpha collected in the Coral Sea near New Caledonia. The structure of these alkaloids featuring the architecturally unique tetracyclic array, coupled with their significant biological activity and scarce availability from marine organisms, has stimulated the synthetic community, resulting in inventive syntheses from eleven different research groups. In this review, these synthetic studies of agelastatin A showcasing elegant and powerful modern synthetic methodologies, are summarized.