Even in recent days, the SN2 reaction on vinylic carbons is not very common. This reaction pathway has been considered as an unlikely mechanism for a long time. However, recent investigations clearly indicate that nucleophilic attack on the σ* orbital of Csp2-LG bond is viable. In this short review, representative examples of this type of reaction are outlined.
2012 社団法人 有機合成化学協会