2013 Volume 71 Issue 11 Pages 1195-1201
Heteroaryl triflones are potential building blocks for the synthesis of novel biologically active compounds as well as functional materials. However, their synthesis has received relatively little attention. In this account, we describe our recent development of three novel synthetic strategies for the regioselective synthesis of heteroaryl triflones: direct trifluoromethanesulfonylation of heteroaromatic compounds, anionic Fries rearrangement of heteroaryl triflates, and transformation from triflyl-containing building blocks.