有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
総説および総合論文
メタセシス重合を用いる医用応用を指向した機能性高分子材料
三木 康嗣井上 達広大江 浩一
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ジャーナル 認証あり

2013 年 71 巻 6 号 p. 601-615

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This review focuses on the development of metathesis polymerization-based polymers for medical application including therapeutic and diagnostic agents. The feature of metathesis polymerization, ring-opening metathesis polymerization (ROMP) and acyclic diene metathesis (ADMET) polymerization, is briefly outlined. The modification methods to synthesize highly functionalized polymers as well as the functional group tolerance under the polymerization conditions are described. The delivery of antitumor drugs, genes, and contrast agents utilizing polymeric nanoparticles is discussed. Recent application of metathesis polymerization-based ionic polymers to antimicrobial materials, cell-penetrating materials, antifouling materials, and signal transducers is also summarized.

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© 2013 社団法人 有機合成化学協会
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