2013 年 71 巻 6 号 p. 601-615
This review focuses on the development of metathesis polymerization-based polymers for medical application including therapeutic and diagnostic agents. The feature of metathesis polymerization, ring-opening metathesis polymerization (ROMP) and acyclic diene metathesis (ADMET) polymerization, is briefly outlined. The modification methods to synthesize highly functionalized polymers as well as the functional group tolerance under the polymerization conditions are described. The delivery of antitumor drugs, genes, and contrast agents utilizing polymeric nanoparticles is discussed. Recent application of metathesis polymerization-based ionic polymers to antimicrobial materials, cell-penetrating materials, antifouling materials, and signal transducers is also summarized.