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有機合成化学協会誌
Vol. 71 (2013) No. 6 p. 637-638

記事言語:

http://doi.org/10.5059/yukigoseikyokaishi.71.637

Review de Debut

Aplyviolene (1) is a diterpene isolated from marine sponge, it has characteristic structures of cis-perhydroazulene and 6-acetoxy-2,7-dioxabicyclo[3.2.1]-octan-3-one moieties. One of the synthetic challenges of 1 is a stereoselective construction of continuous carbon centers at C8 (quaternary carbon) and C14. In this mini review, a total synthesis of aplyviolene by Overman was discussed focusing on the control of those stereocenters by using prochiral nucleophiles of 6 or 10 with electrophiles.

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