有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
Review de Debut
無保護アジリジンの直接的合成法の萌芽と実用的合成への展望
藤間 達哉
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ジャーナル オープンアクセス

72 巻 (2014) 12 号 p. 1400-1401

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An aziridine is a highly strained, triangular molecule that has been recognized as an invaluable synthetic intermediate as well as a structural motif of bioactive molecules. Numerous catalytic/stoichiometric, racemic/asymmetric methods for synthesis of N-protected aziridines have been demonstrated but a practical method for direct N-H aziridine synthesis has been missing for decades despite of its promising utility for drug design. The present review describes recent developments of intermolecular N-H aziridine synthesis as an emerging field of potential application to practical and stereoselective synthesis.

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© 2014 社団法人 有機合成化学協会
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