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Vol. 72 (2014) No. 12 p. 1400-1401



Review de Debut

An aziridine is a highly strained, triangular molecule that has been recognized as an invaluable synthetic intermediate as well as a structural motif of bioactive molecules. Numerous catalytic/stoichiometric, racemic/asymmetric methods for synthesis of N-protected aziridines have been demonstrated but a practical method for direct N-H aziridine synthesis has been missing for decades despite of its promising utility for drug design. The present review describes recent developments of intermolecular N-H aziridine synthesis as an emerging field of potential application to practical and stereoselective synthesis.

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