2014 Volume 72 Issue 3 Pages 303-304
Investigating the function of native biomolecules is an important but challenging task due to the highly complex nature of biological systems. To understand complex biological systems in terms of simple biomolecular interactions, organic chemists have developed many bioorthogonal reactions over the past few years. These bioorthogonal reactions have been applied for the efficient construction of functionalized biomolecules. In this mini review, the development and the applications of such bioorthogonal reactions are described.