2014 年 72 巻 4 号 p. 433-434
(+)-Scholarisine A(1), a akuammiline alkaloid that was first isolated in 2008 from the leaves of Alstonia scholaris, comprises an unprecedented scaffold containing a bridged lactone inscribed in a cagelike skeleton. Structural and biological features of 1 have attracted much attention from synthetic chemists. In this review, total synthesis of 1 reported by Smith’s group and Snyder’s group are described.