2014 年 72 巻 7 号 p. 797-807
Development of chemical glycosylations is crucial to achieve effective synthesis of biologically important oligosaccharides and glycoconjugates in a large amount with high purity. Although tremendous efforts have been done to synthesize complex oligosaccharides for more than several decades, numbers of reliable and versatile methods for chemical glycosylations are limited. Solid-phase synthesis does not seem to be the final answer for oligosaccharide synthesis and automated synthesizers for oligosaccharides in solution-phase are still under development. Therefore, it is particularly important to review recent progress of methodologies for chemical glycosylations carefully and figure out what is a challenge in this research field. In this review article, recent development of glycosylation methods and novel strategies for oligosaccharide synthesis is highlighted from the viewpoint of a synthetic organic chemist.